This toolkit aims to provide nuanced information about key entry points of the six featured technologies within the broader context of ISFM (Figure 3). By compiling up-to-date evidence from research and case studies we discuss the potential benefits for crop production and complementarity with synthetic fertilizer. Critical reflections are made of lessons learned and innovative incentive mechanisms that can help production and use. We also provide examples of how policies and investments can be designed to create practical ways for farmers to access and use technologies that enhance soil health. This toolkit is intended for development organizations and the policy sector to accelerate dissemination and uptake at scale of organic inputs and other amendments with proven ability to maintain and enhance soil health in food production systems of SSA. In light of the Fertilizer and Soil Health Strategy for the next 10 years, the insights provided in this toolkit can aid decision-makers. By assessing the technical aspects and scalability, the toolkit advances understanding to leverage and guide research, commercial investments and policy design. The scope of the assessments in the toolkit includes upland annual and perennial cropping systems such as grains, roots, tubers, and bananas because they represent the largest geographic area and staple food in smallholder systems of SSA.